PI3K -> AKT RSK -> CREB AKT -> CREB MSK1_2 -> CREB TrkA -> SHC FAK -> SHC JNK -> Egr1 AKT -> Egr1 ERK -> Egr1 ETS1 -> Dusp6 CREB -> ARC Egr1 -> ARC SHC -> GRB2 JNK -> JUND ERK -> JUND AKT -> FOS JNK -> FOS ERK -> FOS RSK -> SRF MEKK4 -> Mapk3k uPAR -> uPA_PLAT FOS -> AP1 JUND -> AP1 JUNB -> AP1 Fosl1 -> AP1 MEKK1 -> MKK7 C3G -> RAP1 AP1 -> uPAR TrkA -> PI3K MEK -> ERK ECM -> Itga1 AKT -> Fosl1 JNK -> Fosl1 ERK -> Fosl1 DAG -> PKC Ca2_ -> PKC P38 -> ATF2 JNK -> ATF2 ERK -> ATF2 PLC -> Ca2_ Plasmin -> Mmp3_10 AKT -> KLF10 JNK -> KLF10 ERK -> KLF10 FRS2 -> C3G PLC -> DAG JNK -> KLF4 AKT -> KLF4 ERK -> KLF4 P38 -> MSK1_2 ERK -> MSK1_2 RAS -> RAC1 AKT -> KLF5 P53 -> KLF5 ERK -> KLF5 NGF -> TrkA MEKK4 -> MKK6 RAF -> MEK MEKK1 -> MEK GRB2 -> SOS uPA_PLAT -> Plasmin JNK -> ZFP36 ERK -> ZFP36 MEKK4 -> JNK MKK7 -> JNK AKT -> JUNB JNK -> JUNB ERK -> JUNB Itga1 -> FAK RAP1 -> FAK ATF2 -> Maff JNK -> Maff ERK -> Maff JNK -> KLF6 P53 -> KLF6 NPYY1 -> G_i_o_ ERK -> RSK CREB -> CITED2 P53 -> CITED2 ERK -> CITED2 RAC1 -> MEKK1 JNK -> Stat3 ERK -> Stat3 JNK -> ETS1 ERK -> ETS1 Mmp3_10 -> ECM AP1 -> Npy Npy -> NPYY1 SOS -> RAS RAC1 -> MEKK4 AKT -> MYC JNK -> MYC ERK -> MYC JNK -> KLF2 AKT -> KLF2 ERK -> KLF2 TrkA -> PLC G_i_o_ -> PLC AKT -> BTG2 JNK -> BTG2 MKK6 -> P38 Mapk3k -> P38 TrkA -> FRS2 RAS -> RAF PKC -> RAF JNK -> P53 AKT -> P53 ERK -> P53 $AKT: PI3K $AP1: (((JUNB | JUND) | Fosl1) | FOS) $ARC: (CREB | Egr1) $ATF2: ((P38 | ERK) | JNK) $BTG2: (AKT | JNK) $C3G: FRS2 $CITED2: ((CREB | ERK) | P53) $CREB: ((MSK1_2 | AKT) | RSK) $Ca2_: PLC $DAG: PLC $Dusp6: ETS1 $ECM: Mmp3_10 $ERK: MEK $ETS1: (JNK | ERK) $Egr1: ((JNK | ERK) | AKT) $FAK: (Itga1 | RAP1) $FOS: ((AKT | JNK) | ERK) $FRS2: TrkA $Fosl1: ((AKT | ERK) | JNK) $GRB2: SHC $G_i_o_: NPYY1 $Itga1: ECM $JNK: (MEKK4 | MKK7) $JUNB: ((ERK | AKT) | JNK) $JUND: (JNK | ERK) $KLF10: ((AKT | ERK) | JNK) $KLF2: ((ERK | JNK) | AKT) $KLF4: ((JNK | ERK) | AKT) $KLF5: ((P53 | AKT) | ERK) $KLF6: (P53 | JNK) $MEK: (MEKK1 | RAF) $MEKK1: RAC1 $MEKK4: RAC1 $MKK6: MEKK4 $MKK7: MEKK1 $MSK1_2: (ERK | P38) $MYC: ((JNK | AKT) | ERK) $Maff: ((ERK | JNK) | ATF2) $Mapk3k: MEKK4 $Mmp3_10: Plasmin $NPYY1: Npy $Npy: AP1 $P38: (MKK6 | Mapk3k) $P53: ((AKT | ERK) | JNK) $PI3K: TrkA $PKC: (DAG | Ca2_) $PLC: (G_i_o_ | TrkA) $Plasmin: uPA_PLAT $RAC1: RAS $RAF: (RAS | PKC) $RAP1: C3G $RAS: SOS $RSK: ERK $SHC: (TrkA | FAK) $SOS: GRB2 $SRF: RSK $Stat3: (ERK | JNK) $TrkA: NGF $ZFP36: (JNK | ERK) $uPAR: AP1 $uPA_PLAT: uPAR